Techniques and Equipment
Functional Testing
Physical Function
- rotarod (overall motor function)
- treadmill (endurance, aerobic exercise capacity)
- grip meter (limb strength)
- inverted cling (full body strength/endurance)
- voluntary wheel running, VWR (volitional exercise and activity rate)
Cognitive Function
- open field (anxiety and exploratory behavior)
- y-maze (working memory)
- novel object recognition (memory)
- puzzle box (executive function)
Contractile Function
- ex vivo / in vitro contractile physiology (force, velocity and power of contraction in soleus, extensor digitorum longus, or diaphragm muscle)
- in vivo contractile physiology (maximum isometric plantar flexor, quadriceps, or dorsiflexor torque output)
Cardiovascular Function
- blood pressure
- echocardiograph
Gene Expression
- NGS RNAseq
- rt-qPCR
Protein Expression and Cell Signaling
- mass spectrometry
- western immunoblotting
Immunohistochemistry
- muscle cell cross-sectional area and fiber typing
- muscle cell culture characterization
- succinate dehydrogenase activity
- capillarization
Mitochondrial Function
- citrate synthase activity assay
- high resolution respirometry
Gain/Loss of Function
- viral vectors
- siRNA
Cell Culture
Immortalized Lines
- C2C12
- MCR5
Primary Cells
- human primary myocytes
- mouse primary myocytes
Preclinical Exercise Models
- HIIT (high intensity interval training)
- VWR (voluntary wheel running)
- HIFT (high intensity functional training) or power training
Coming Soon:
- MICT (moderate intensity continuous training)
- Acute resistance training