Publications

RESEARCH ARTICLES IN PEER-REVIEWED JOURNALS

 (* = equal contribution with primary author credit; # = corresponding author)

  1. Pajski ML, Byrd C, Nandigama N, Seguin E, Seguin A, Fennell A, Graber TG#. Endurance exercise preserves physical function in adult and older male C57BL/6 mice: high intensity interval training (HIIT) versus voluntary wheel running (VWR). Front Aging. 2024 Mar 7;5:1356954. doi: 10.3389/fragi.2024.1356954. PMID: 38523671; PMCID: PMC10958787.
  2. Maroto R, Graber TG, Romsdahl TB, Kudlicki A, Russell WK, Rasmussen BB#. Metabolomic and Lipidomic Signature of Skeletal Muscle with Constitutively Active Mechanistic Target of Rapamycin Complex 1. J Nutr. 2023 Dec;153(12):3397-3405. doi: 10.1016/j.tjnut.2023.10.016. Epub 2023 Oct 28. PMID: 37898335; PMCID: PMC10739780.
  3. Graber TG#, Maroto R, Thompson J, Widen S, Man Z, Pajski ML, Rasmussen BB. Skeletal Muscle Transcriptome Alterations Related to Physical Function Decline in Older Mice. J. Ageing Longev. 2023;3(2):159-178. doi: https://doi.org/10.3390/jal3020013   PMID: 37876943 PMCID: PMC10597580
  4. Brightwell CR, Graber TG, Brightwell BD, Borkowski M, Noehren B, Fry CS. In vivo Measurement of Knee Extensor Muscle Function in Mice. J. Vis. Exp. 2021;169:e62211. doi: https://doi.org/10.3791/62211  PMID: 33749677 PMCID: PMC8095664
  5. Graber TG#, Maroto R, Fry CS, Brightwell CR, Rasmussen BB. Measuring Exercise Capacity and Physical Function in Adult and Older Mice [published online ahead of print, 2020 Aug 21]. J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):819-824. doi: https://doi.org/10.1093/gerona/glaa205 PMID: 32822475; PMCID: PMC8087272
  6. Graber TG, Fandrey K, Thompson LV#. Novel individualized power training protocol preserves physical function in adult and older mice. Geroscience. 2019;41(2):165-183. doi: https://doi.org/10.1007/s11357-019-00069-z PMID: 31076998  PMCID: PMC6544743
  7. Kim J-H, Graber TG, Liu H, Asakura A, Thompson LV#. Increasing MLC3f Protects Against a Decline in Contractile Velocity. PLoS One. 2019;14(4):e0214982. doi: https://doi.org/10.1371/journal.pone.0214982  eCollection 2019. PMID: 30964931 PMCID: PMC6456215
  8. Neelakantan H*, Brightwell CR*, Graber TG, Maroto R, Wang H-Y L, McHardy SF, Papaconstantinou J, Fry CS#, Watowich SJ#. Small molecule nicotinamide N-methyltransferase inhibitors activate senescent muscle stem cells and improve regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492. doi: https://doi.org/10.1016/j.bcp.2019.02.008  PMID: 30753815 PMCID: PMC6469996
  9. Graber TG, Fry CS, Brightwell CR, Moro T, Maroto R, Bhattarai N, Porter C, Wakamiya M, Rasmussen BB#. Skeletal Muscle Specific Knockout of DEP domain-containing 5 Increases mTORC1 Signaling, Muscle Cell Hypertrophy, and Mitochondrial Respiration. J Biol Chem. 2019;15;294(11):4091-4102. doi: https://doi.org/10.1074/jbc.RA118.005970. PMID: 30635399 PMCID: PMC6422100
  10. Moro T, Brightwell CR, Deer RR, Graber TG, Galvan E, Fry CS, Volpi E, Rasmussen BB#. Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training. J Nutr. 2018 Jun 1;148(6):900-909. doi: https://doi.org/10.1093/jn/nxy064 PMID: 29796648 PMCID: PMC6251608
  11. Graber TG, Rawls BL, Tian B, Durham WJ, Brightwell CR, Brasier AR, Rasmussen BB, Fry CS#. Repetitive TLR-3-mediated Lung Damage Induces Skeletal Muscle Adaptations and Cachexia. Exp. Gerontol. 2018 Feb 13. pii: S0531-5565(17)30667-8. doi: https://doi.org/10.1016/j.exger.2018.02.002  PMID: 29452288 PMCID: PMC5911410
  12. Graber TG, Borack MS, Reidy PT, Volpi E, Rasmussen BB#. Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle.  Nutr Metab (Lond). 2017;May 11;14:35. doi: https://doi.org/10.1186/s12986-017-0187-1 PMID: 28503190 PMCID: PMC5426042
  13. Graber TG, Kim J-H, McLoon LK, Grange RW, Thompson LV#. C57BL/6 Lifespan Study: Age-Related Declines in Muscle Power Production and Contractile Velocity. Age. 2015;37:36-. doi: https://doi.org/10.1007/s11357-015-9773-1 PMID: 25893911 PMCID: PMC4401475
  14. Graber TG*, Ferguson-Stegall L*, Liu H, Thompson LV#. Voluntary Aerobic Exercise Reverses Frailty in Old Mice. J Gerontol A Biol Sci Med Sci. 2015;70(9):1045-1058. doi: https://doi.org/10.1093/gerona/glu163 PMID: 25271307 PMCID: PMC4553716
  15. Chen, CJ, Graber TG, Bratten, WM, Ferrington DA, Thompson, LV#. Immunoproteasome in Animal Models of Duchenne Muscular Dystrophy. Journal of Muscle Research and Cell Motility. 2014;35(2):191-201. doi: https://doi.org/10.1007/s10974-014-9385-x  PMID: 24934129 PMCID: PMC4130177
  16. Liu H*, Graber TG*, Ferguson-Stegall L, Thompson LV#. Clinically Relevant Frailty Index for Mice. J Gerontol A Biol Sci Med Sci. 2014;69(12):1485-1491. doi: https://doi.org/10.1093/gerona/glt188 PMID: 24336799 PMCID: PMC4271019
  17. Graber TG, Ferguson-Stegall L, Kim J-H, Thompson LV#. C57BL/6 Neuromuscular Healthspan Scoring System. J Gerontol A Biol Sci Med Sci. 2013;68(11):1326-1336. doi: https://doi.org/10.1093/gerona/glt032  PMID: 23585418 PMCID: PMC3805297

          REVIEW ARTICLES, BOOK CHAPTERS, DISSERTATIONS

          1. Graber TG, Rasmussen BB. Nutrient Sensing and mTORC1 Regulation in Sarcopenia. In: Meynial-Denis D, ed. Sarcopenia: Molecular, Cellular, and Nutritional Aspects – Applications to Humans. 1st ed. Boca Raton, FL: CRC Press; 2019;Chapter 5:73-86. (Book Chapter)
          2. Graber TG. (2015c). Investigation of Sarcopenia in a Murine Model: Symptoms of Age-Related Neuromuscular Decline and Resistance Training Intervention. Retrieved via WWW from the University of Minnesota Digital Conservancy at http://hdl.handle.net/11299/188830. (Dissertation)

          ARTICLE PREPRINTS

          (*=equal contribution with primary author credit; # = corresponding author)

          1. Graber TG#, Maroto R, Thompson J, Widen S, Man Z, Pajski ML, Rasmussen BB. Skeletal Muscle Transcriptome Alterations Related to Physical Function Decline in Older Mice. 2021. Pre-print published at bioRxiv.org. doi: https://doi.org/10.1101/2021.05.17.444371; (also under review)
          2. Pajski ML*, Byrd C, Nadigama N, Seguin E, Seguin A, Fennel A, Graber TG#*.  Endurance Exercise Training Modes to Improve Physical Function in Older Mice: HIIT vs. VWR. Pre-print published at bioRxiv.org. doi: https://doi.org/10.1101/2021.05.20.445050; (also under review)

           

          ARTICLES UNDER REVIEW

          ARTICLES IN PREPARATION

          1. 2024 Graber TG#, Pajski ML, Maroto R. Longitudinal Decline of Exercise Capacity in Male and Female Mice. (in preparation for submission in spring 2024)
          2. 2024 Graber TG#, Pajski ML, Huang W. The Intersection of Aging, High Intensity Exercise Training, and the Baseline Transcriptome in Mouse Skeletal Muscle  (in preparation for submission in summer 2024)
          3. 2024 Stephenson J, Carter H, Tran T, Szatmari E, Graber TG#. High Intensity Interval Training Intervention For Cognitive and Phsyical Function in Middle -Aged Mice (in preparation for submission in summer 2024)
          4. 2024 Graber TG#, Pajski ML,  Maroto R, Rontoyanni V, Porter C, Rasmussen BB, Wanagat J. Mitochondrial Dysfunction as a Driver of Age-Related Loss of Physical Performance? (in preparation for submission in fall 2024)
          5. 2024 Graber TG#, McCrary J, Webster A, Nandigama N, Pajski ML. Age-related calcium handling  abnormalities in skeletal muscle  driving contractile dysfunction and loss of exercise capacity. (in preparation for submission in fall 2024)

          PUBLISHED ABSTRACTS

          1. Graber TG#, Pajski ML, Byrd C, Nandigama N, Fennel A, Seguin E, Seguin. Maintenance of Physical Function in Adult and Older Adult Mice Using Aerobic Exercise. Innovation in Aging. 2021;5(S1):982. doi: https://doi.org/10.1093/geroni/igab050
          2. Graber TG#, Christopher Byrd, Emily Seguin, Anna Seguin, Alyssa Fennel, Nainika Nandigama. Endurance Exercise Training Modes to Improve Physical Function in Older Mice: HIIT vs. VWR. Innovation in Aging. 2020;4(S1):888. doi: https://doi.org/10.1093/geroni/igaa057.3276
          3. Brightwell CR, Graber TG, Marota Rosario, Noehren B, Fry CS. Myostatin Mediates Quadriceps Muscle Atrophy And Fibrosis Rapidly After ACL Transection In Novel Murine Model: 355 Board #171 May 27 10:30 AM – 12:00 PM. Medicine & Science in Sports & Exercise. 2020;52(7S):85-85. doi: https://doi.org/10.1249/01.mss.0000670960.03850.22
          4. Moro T,  Graber TG, Reidy PT, Volpi E, Rasmussen BB. Aging Induces A Differential Muscle Transcriptome Profile Following Resistance Exercise Training: 1326 Board #8 May 28 9:30 AM – 11:30 AM. Medicine & Science in Sports & Exercise. 2020;52(7S):348-348. doi: https://doi.org/10.1249/01.mss.0000677548.03141.9d
          5. Graber TG#, Marota R, Thompson J, Widen S, Rasmussen BB. Transcriptome Alterations Associated with Age-Related Decline in Physical Function. Innovation in Aging. 2019;3(S1). PMCID: PMC6845708 doi: https://doi.org/10.1093/geroni/igz038.3199
          6. Graber TG, Fry CS, Marota Rosario, Rasmussen BB. Exercise Capacity and Physical Function in Older Mice. Pathobiol Aging Age Relat Dis. 2019;9(S1):1591258. doi: https://doi.org/10.1080/20010001.2019.1591258
          7. Graber TG, Fry CS, Maroto Rosario, Rasmussen BB. CFAB: Comprehensive Functional Assessment Battery for Older Mice. Innovation in Aging. 2018;2(S1):879. PMCID: PMC6239355 doi: https://doi.org/10.1093/geroni/igy031.3281
          8. Graber TG, Fry CS, Rasmussen BB. (2018). Comprehensive Evaluation of Physical Function in Older Mice. GeroScience. 2018;40:405. doi: https://doi.org/10.1007/s11357-018-0041-z
          9. Moro T, Brightwell CR, Deer RR, Graber TG, Galvan E, Fry CS, Volpi E, Rasmussen BB. Effect Of Resistance Exercise Training On Anabolic Resistance To Amino Acids In Healthy Older Adults. Medicine & Science in Sports & Exercise. 2018;50(5S):370. doi: https://doi.org/10.1249/01.mss.0000536300.72296.fb
          10. Graber TG, Rawls B, Tian B, Durham W, Brasier A, Rasmussen BB, Fry CS. (2017). COPD Cachexia in a Murine Model. Innovation in Aging. 2017;1(suppl_1): 425-426. doi: https://doi.org/10.1093/geroni/igx009
          11. Lambert B, Kato T, Reidy P, Graber TG, Borack M, Deer R, Rasmussen BB, Volpi E. Whey Hydrolysate Supplementation Following Resistance Exercise Elicits Similar Anabolic Responses in Both Young and Older Adults: 2334 Board# 347 June 13. Medicine & Science in Sports & Exercise. 2017;49(5s):660-661. doi: https://doi.org/10.1249/01.mss.0000518741.65304.18
          12. Graber TG, Rawls B, Tian B, Durham W, Brasier A, Rasmussen BB, Fry CS. Chronic Obstructive Pulmonary Disease Mouse Model Displays Accelerated Aging Sarcopenic Phenotype. Gerontologist. 2016;56(Suppl_3): 111-112. doi: https://doi.org/10.1093/geront/gnw162.435
          13. Moro T, Deer RR, Graber TG, Volpi E, Rasmussen BB. Effect of 12 week of resistance exercise training on muscular protein anabolic resistance in older adults. SISMES VIII NATIONAL CONGRESS. Sport Sci Health. 2016;12:1–91. doi: https://doi.org/10.1007/s11332-016-0305-x
          14. Graber TG, Borack MS, Reidy PT, Volpi E, Rasmussen BB. Genes Associated with Amino Acid Sensing in Human Skeletal Muscle are Altered by Amino Acid Availability and Acute Lysosomal Perturbation. The FASEB Journal. 2016;30(S1): 904.22. doi: https://doi.org/10.1186/s12986-017-0187-1
          15. Graber TG, Drummond MJ, Borack MS, Volpi E, Rasmussen BB. Myoregulin mRNA Expression is Decreased in Older Adults After One Week of Bedrest. Gerontologist. 2015;55(S2):NP,#369. doi: https://doi.org/10.1093/geront/gnv158
          16. Graber TG, Kim J-H, Grange R, McLoon L, Thompson LV. Age-Associated Declines in Power and Contractile Velocity Increased Under Heavily Loaded Conditions. Gerontologist. 2014;54(S2):689. doi: https://doi.org/10.1093/geront/gnu106:682
          17. Graber TG, Thompson LV. Voluntary Resistance Training Protocol for Mice: Model System Mimetic of Human Voluntary Weight Lifting to Investigate Sarcopenia-Related Cellular Mechanisms. Gerontologist. 2013;53(S1):531. doi: https://doi.org/10.1093/geront/gnt151
          18. Kim JH, Torgerud W, Graber TG, Liu H, Thompson LV. Single Muscle Fiber Power Generation with Non-Weightbearing Conditions: Does Muscle of Origin Play a Role? The FASEB Journal. 2013;27(S1):lb711. doi: https://doi.org/10.1096/fasebj.27.1_supplement.lb711
          19. Ferguson-Stegall L, Graber TG, Thompson LV. Voluntary wheel running can induce functional improvements in young and elderly mice. Experimental Gerontology. 2013;7(48):690-690. doi: https://doi.org/10.1016/j.exger.2013.05.027
          20. Ferguson-Stegall L, Graber TG, Thompson LV. Functional Adaptations to Voluntary Wheel Running in Young and Elderly Mice. Medicine and Science in Sports and Exercise. 2012;44(5S):421-422. doi: https://doi.org/10.1249/01.mss.0000417529.22755.ed
          21. Kim JH, Graber TG, Stegall LF, Liu H, Asakura A, Thompson LV. The Effect Of Myosin Light Chain 3f On Inactivity-induced Decline In Contractile Velocity In Type II Single Muscle Fibers. Medicine and Science in Sports and Exercise. 2012;44(5S):351-351. doi: https://doi.org/10.1249/01.mss.0000417529.22755.ed
          22. Graber TG, Chen CN, Mosser KHH, Bratten WM, Ferrington DA, Thompson LV. Mouse models of muscle remodeling. Experimental Gerontology. 2011;46(2):213-213.doi: https://doi.org/10.1016/j.exger.2010.11.027